Synthesis of coenzyme A ester of retinoic acid: intermediate in vitamin A metabolism.
نویسندگان
چکیده
Coenzyme A esters of all-trans- and 13-cis-retinoic acid were synthesized for use in studying vitamin A metabolism. The esters were obtained by two different synthetic methods starting from retinoic acids, which were converted to activated succinimidyl esters or anhydrides. These in turn were coupled with coenzyme A to form their respective thioesters. The retinoyl coenzyme A esters were purified by reverse-phase high performance liquid chromatography.
منابع مشابه
Synthesis, Analysis and Characterization of the Coenzyme A Esters of 0-SuccinyIbenzoic Acid, an Intermediate in Vitamin K2 (Menaquinone) Biosynthesis
Rainer Kolkmann and Eckhard Leistner Institut für Pharmazeutische Biologie, Rheinische Friedrich-Wilhelms-Universität, D-5300 Bonn, Bundesrepublik Deutschland Z. Naturforsch. 42c, 542-552 (1987); received October 27, 1986/January 19, 1987 o-Succinylbenzoic Acid Coenzyme A Ester, 1,4-Dihydroxy-2-naphthoic Acid, Menaquinone, Vitamin K, Biosynthesis One of the carboxyl groups of o-succinylbenzoic ...
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 83 18 شماره
صفحات -
تاریخ انتشار 1986